Reversal Syndrome

The XY chromosome configuration determines males and the XX females, but in sex reversal syndrome a male with XY will develop female sex organs or women with XX will have male characteristics.

Sex reversal syndrome can be divided into 46, XX male sex reversal syndrome and 46, XY female sex reversal syndrome.

Just a simple duplication of the gene in a double dose apparently leads to sex reversal,” Robin Lovell-Badge, of the MRC National Institute for Medical Research, told Reuters.

Hines et al identified patients with SRY mutations that caused XY sex reversal female individuals.

De la Chapelle A, Hastbacka J, Korhonen T, Maenpaa J.